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When Ellen M. Roche， 24， volunteered for the asthma experiment， she didn't expect to benefit from it——except for the $365 she'd be paid. Unlike clinical trials， in which most patients hope that an experimental therapy will help them， this study was designed just to answer a basic question： how does the way a normal lung reacts to irritants shed light on how an asthmatic lung responds? To find out， scientists led by Dr. Alkis Togias of Johns Hopkins University had Roche and other healthy volunteers inhale a drug called hexamethonium. Almost immediately Roche began to cough and feel short of breath. Within weeks her lungs failed and her kidneys shut down. On June 2 Roche died——a death made more tragic by the possibility that it was preventable. Last week the federal Office for Human Research Protections (OHRP) ruled that Hopkins's system for protecting human subjects is so flawed that virtually all its U.S.-supported research had to stop.
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